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Results for "

Mycobacterium tuberculosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (1) Androgen Receptor (1) Antibiotic (24) Antifolate (1) Apoptosis (2) ATP Synthase (1) Autophagy (3) Bacterial (142) Biochemical Assay Reagents (1) Calcium Channel (1) Cytochrome P450 (1) DNA/RNA Synthesis (3) Drug Metabolite (1) Endogenous Metabolite (4) Epigenetic Reader Domain (1) Fungal (2) HIV (1) HSV (1) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (1) MMP (1) mTOR (1) Parasite (3) Potassium Channel (2) PROTACs (1) Proton Pump (1) Sodium Channel (1) Thymidylate Synthase (3) TNF Receptor (2) Toll-like Receptor (TLR) (1) Tyrosinase (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Infection (156) Inflammation/Immunology (15) Metabolic Disease (1) Neurological Disease (2)

By Targets:

ADC Cytotoxin (1)

Akt (1)

Androgen Receptor (1)

Antibiotic (24)

Antifolate (1)

Apoptosis (2)

ATP Synthase (1)

Autophagy (3)

Bacterial (142)

Biochemical Assay Reagents (1)

Calcium Channel (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (3)

Drug Metabolite (1)

Endogenous Metabolite (4)

Epigenetic Reader Domain (1)

Fungal (2)

HIV (1)

HSV (1)

Isotope-Labeled Compounds (2)

Mitochondrial Metabolism (1)

MMP (1)

mTOR (1)

Parasite (3)

Potassium Channel (2)

PROTACs (1)

Proton Pump (1)

Sodium Channel (1)

Thymidylate Synthase (3)

TNF Receptor (2)

Toll-like Receptor (TLR) (1)

Tyrosinase (1)

By Research Areas:

Cancer (8)

Cardiovascular Disease (1)

Infection (156)

Inflammation/Immunology (15)

Metabolic Disease (1)

Neurological Disease (2)

166

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-157431

Mycobacterium Tuberculosis-IN-2	ADC Cytotoxin	Infection
Mycobacterium Tuberculosis-IN-2 (Compound 29) is a bacterial inhibitor that effectively inhibits Mycobacterium Tuberculosis. Mycobacterium Tuberculosis-IN-2 can be used in tuberculosis research (MIC = 0.07-0.16 μM) .

HY-151550

Mtb-cyt-bd oxidase-IN-3	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-3 (compound 1u) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.36 μM. Mtb-cyt-bd oxidase-IN-3 inhibits the growth of Mycobacterium tuberculosis (MIC=32 μM). Mtb-cyt-bd oxidase-IN-3 can be used in tuberculosis research .

HY-147047

InhA-IN-2

Bacterial Infection

InhA-IN-2 (Compound 23) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 0.31 μM .

InhA-IN-2	Bacterial	Infection
InhA-IN-2 (Compound 23) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 0.31 μM .

HY-128866

TBAJ-876	Bacterial	Infection
TBAJ-876 is the inhibitor of mycobacterium tuberculosis. TBAJ-876 is the analogue of the anti-tuberculosis agent Bedaquiline. TBAJ-876 has the potential for the research of tuberculosis .

HY-156022

Antitubercular agent-41	Bacterial	Neurological Disease
Antitubercular agent-41 (Compound 106) is an antitubercular agent that can be used in the study of Mycobacterium tuberculosis infection .

HY-151548

Mtb-cyt-bd oxidase-IN-1	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-1 (compound 1x) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.13 μM. Mtb-cyt-bd oxidase-IN-1 can be used in tuberculosis research .

HY-155648

Tuberculosis inhibitor 6	Bacterial	Infection
Tuberculosis inhibitor 6 (compound 2c) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC₉₀ of ≤1.66 μM) and Mycobacterium marinum (MIC₉₀ of 2.65 μM) .

HY-155649

Tuberculosis inhibitor 7	Bacterial	Infection
Tuberculosis inhibitor 7 (compound 2d) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC₉₀ of 0.63 μM) and Mycobacterium marinum (MIC₉₀ of 0.63 μM) .

HY-155650

Tuberculosis inhibitor 8	Bacterial	Infection
Tuberculosis inhibitor 8 (compound 3b) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC₉₀ of 0.69 μM) and Mycobacterium marinum (MIC₉₀ of 0.69 μM) .

HY-155651

Tuberculosis inhibitor 9	Bacterial	Infection
Tuberculosis inhibitor 9 (compound 3d) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC₉₀ of 0.64 μM) and Mycobacterium marinum (MIC₉₀ of 0.64 μM) .

HY-N10992

Pomolic acid 3-acetate

Bacterial Infection

Pomolic acid 3-acetate is an antitubercular agent with a MIC of 32 μM against Mycobacterium tuberculosis H₃₇Rv .
HY-151206

PknB-IN-2

Bacterial Infection

PknB-IN-2 (Compound 10) is a Mycobacterium tuberculosis protein kinase B (PknB) inhibitor with an IC₅₀ of 12.1 μM .

Pomolic acid 3-acetate	Bacterial	Infection
Pomolic acid 3-acetate is an antitubercular agent with a MIC of 32 μM against Mycobacterium tuberculosis H₃₇Rv .

PknB-IN-2	Bacterial	Infection
PknB-IN-2 (Compound 10) is a Mycobacterium tuberculosis protein kinase B (PknB) inhibitor with an IC₅₀ of 12.1 μM .

HY-151551

Mtb-cyt-bd oxidase-IN-4	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-4 (compound 1g) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.25 μM. Mtb-cyt-bd oxidase-IN-4 inhibits the growth of Mycobacterium tuberculosis (MIC=8 μM). Mtb-cyt-bd oxidase-IN-4 can be used in tuberculosis research .

HY-139595

Polyketide synthase 13-IN-2	Bacterial	Infection Inflammation/Immunology
Polyketide synthase 13-IN-2 (comp 42) is a polyketide synthase 13 inhibitor against Mycobacterium tuberculosis, with an MIC of 0.25 μg/mL .

HY-147000

DNA Gyrase-IN-1	Bacterial DNA/RNA Synthesis	Infection
DNA Gyrase-IN-1 (compound 42) is a potent and selective DNA gyrase inhibitor with an IC₅₀ value of 2.6 µM. DNA Gyrase-IN-1 has high inhibitory activity against Mycobacterium tuberculosis (Mtb) with MIC of 0.49 µM. DNA Gyrase-IN-1 can be used for researching tuberculosis .

HY-150589

InhA-IN-4

Bacterial Infection

InhA-IN-4 (TU14) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 15.6 μM .
HY-156421

QST4

Bacterial Infection

QST4 has antitubercular activity, with the MIC value of 6.25 μM in Mycobacterium tuberculosis H37Rv .

InhA-IN-4	Bacterial	Infection
InhA-IN-4 (TU14) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 15.6 μM .

QST4	Bacterial	Infection
QST4 has antitubercular activity, with the MIC value of 6.25 μM in Mycobacterium tuberculosis H37Rv .

HY-160678

InhA-IN-7	Bacterial	Infection
InhA-IN-7 (Compound 11) is a Triclocan (HY-B1119) derivative with inhibitory activity towards enoyl-acyl carrier protein reductase (InhA) with an IC₅₀ of 96 nM. InhA-IN-7 inhibits proliferations of Mycobacterium tuberculosis wildtype and mutant strains with MICs ranging from 19 to 75 μM .

HY-150588

InhA-IN-3

Bacterial Infection

InhA-IN-3 (Compound TU12) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 17.7 μM .

InhA-IN-3	Bacterial	Infection
InhA-IN-3 (Compound TU12) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC₅₀ of 17.7 μM .

HY-151549

Mtb-cyt-bd oxidase-IN-2	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-2 is an inhibitor of Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) with an IC₅₀ value of 0.67 μM. Mtb-cyt-bd oxidase-IN-2 inhibits the growth of Mycobacterium tuberculosis with a MIC value of 256 μM. Mtb-cyt-bd oxidase-IN-2 can be used for the research of infection .

HY-152495

MenA-IN-1	Others	Infection
MenA IN-1 is an effective inhibitor of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis (MTB) with an IC₅₀ value of 13 µM and an GIC₅₀ value of 8 µM. MenA IN-1 can be used to curb the continuous spread of tuberculosis .

HY-151553

Mtb-cyt-bd oxidase-IN-6	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-6 is a potent Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC₅₀ value of 0.35 μM. Mtb-cyt-bd oxidase-IN-6 can effectively inhibit the growth of Mtb (MIC= 4 μM). Mtb-cyt-bd oxidase-IN-6 can be used in the study of tuberculosis .

HY-163181

MSU-43085	Bacterial	Infection
MSU-43085 is an orally active MmpL3 inhibitor of Mycobacterium tuberculosis (Mtb). MSU-43085 effectively inhibits Mtb in an acute murine tuberculosis infection model. MSU-43085 can be used in tuberculosis research .

HY-125965

BioA-IN-13

Bacterial Infection

BioA-IN-13 is a potent, cell permeable and whole-cell active inhibitor of Mycobacterium tuberculosis BioA enzyme .

BioA-IN-13	Bacterial	Infection
BioA-IN-13 is a potent, cell permeable and whole-cell active inhibitor of Mycobacterium tuberculosis BioA enzyme .

HY-152534

MenA-IN-2	Others	Infection
MenA-IN-2 (Compound 11) is an inhibitor of 1,4-dihydroxy-2-naphthoate prenyltransferase (MenA). MenA-IN-2 inhibits MenA with an IC₅₀ value of 22 µM and inhibits Mycobacterium tuberculosis (*Mtb) with an GIC₅₀* value of 10 µM. MenA-IN-2 can curb the continuous transmission of Mtb .

HY-139398

TBI-223 1 Publications Verification	Bacterial	Infection
TBI-223 is an orally bioavailable oxazolidinone antibiotic and an antimicrobial. TBI-223 shows activity against Mycobacterium tuberculosis (Mtb) .

HY-151806

HadAB-IN-1	Bacterial	Infection Inflammation/Immunology
HadAB-IN-1 is a potent HadAB inhibitor. HadAB-IN-1 inhibits HadAB enzyme complexes activity with an IC₅₀ value of 0.03 μM. HadAB-IN-1 also affects mycolic acid biosynthesis in Mycobacterium tuberculosis (Mtb). HadAB-IN-1 can be used for the research of tuberculosis (TB) .

HY-145985

CBR-3465

Bacterial Infection

CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .
HY-145986

CBR-6672

Bacterial Infection

CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .

CBR-3465	Bacterial	Infection
CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .

CBR-6672	Bacterial	Infection
CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .

HY-12904

TCA1	Bacterial	Infection
TCA1 is a small molecule with activity against agent-susceptible and -resistant Mycobacterium tuberculosis (Mtb). TCA1 inhibits enzymes involved in cell wall and molybdenum cofactor biosynthesis, such as DprE1 and MoeW .

HY-N1160

Tetrahydroxysqualene	Bacterial	Infection
Tetrahydroxysqualene is a triterpene, possessing antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 10.0 μg/mL. Tetrahydroxysqualene can be isolated from the methanolic extracts of Rhus taitensis Guill .

HY-115448

Bio-AMS	Bacterial	Infection
Bio-AMS is a potent bacterial biotin protein ligase inhibitor. Bio-AMS possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis .

HY-115900

Tuberculosis inhibitor 4	Bacterial	Infection
Tuberculosis inhibitor 4 (compound 16), a mandelic acid-based spirothiazolidinone, has potent antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv with the high inhibition value 98% at lower than 6.25 µg/mL concentration .

HY-115448A

Bio-AMS TFA	Bacterial	Infection
Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. Bio-AMS (TFA) possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis .

HY-145741

MptpB-IN-1	Antibiotic	Infection
MptpB-IN-1 (Compound 13) is a potent and orally active inhibitor of MptpB. Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. MptpB-IN-1 reduces multidrug-resistant mycobacterium tuberculosis survival and infection burden .

HY-154807

DQn-1	Bacterial	Infection
DQn-1 is a potent antifolate with activity against Mycobacterium tuberculosis (Mtb) (MIC₉₀=0.03 µM). DQn-1 directly inhibits DHFR enzyme activity, with IC₅₀s of 8.7 and 7.6 nM for Mtb and human DHFR enzyme, respectively .

HY-146298

Mt KARI-IN-1

Bacterial Infection

Mt KARI-IN-1 (Lead compound) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a K_i value of 3.06 μM .

Mt KARI-IN-1	Bacterial	Infection
Mt KARI-IN-1 (Lead compound) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a K_i value of 3.06 μM .

HY-115884

PptT-IN-3	Bacterial	Infection Inflammation/Immunology
PptT-IN-3 (compound 5p) is a potent inhibitor of with phosphopantetheinyl phosphoryl transferase (PptT) an IC₅₀ of 3.5 μM. Phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. PptT-IN-3 has the potential for the research of tuberculosis .

HY-115883

PptT-IN-2	Bacterial	Infection Inflammation/Immunology
PptT-IN-2 (compound 5k) is a potent inhibitor of with phosphopantetheinyl phosphoryl transferase (PptT) an IC₅₀ of 2.5 μM. Phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. PptT-IN-2 has the potential for the research of tuberculosis .

HY-115882

PptT-IN-1	Bacterial	Infection Inflammation/Immunology
PptT-IN-1 (compound 5j) is a potent inhibitor of with phosphopantetheinyl phosphoryl transferase (PptT) an IC₅₀ of 2.8 μM. Phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. PptT-IN-1 has the potential for the research of tuberculosis .

HY-148111

Antitubercular agent-33

Bacterial Infection

Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb) .

Antitubercular agent-33	Bacterial	Infection
Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb) .

HY-161178

LK-60	Bacterial	Infection
LK-60 is a potent DprE1 inhibitor. LK-60 effectively inhibits the proliferation of Mycobacterium tuberculosis. LK-60 has good safety profiles to gut microbiota and human cells .

HY-151941

MtInhA-IN-1	Bacterial	Infection
MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC₅₀ of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM .

HY-144325

CYP121A1-IN-1	Cytochrome P450	Infection
CYP121A1-IN-1 is a potent CYP121A1 inhibitor with favorable activity against Mycobacterium tuberculosis (H37Rv MIC₉₀∼6.25 μM, ∼2.2 μg/mL). CYP121A1-IN-1 can markedly reduce the production of mycocyclosin via inhibiting the CYP121A1 mediated turnover of cyclo(l-tyrosyl-l-tyrosyl) to mycocyclosin .

HY-N3661

(24S)-Cycloartane-3β,24,25-triol	Bacterial	Infection
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .

HY-101867

AU1235 2 Publications Verification	Bacterial	Infection Cancer
AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane .

HY-120733

Calpinactam FKI-4905	Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .

HY-P5623B

RVG TFA RVG29 TFA; RDP TFA; Rabies Virus Glycoprotein-29 TFA	Bacterial	Infection
RVG TFA is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

HY-143452

MtTMPK-IN-4	Tyrosinase Bacterial	Inflammation/Immunology
MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC₅₀ of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent .

HY-P5623

RVG RVG29; RDP; Rabies Virus Glycoprotein-29	Bacterial	Infection
RVG (RVG29) is a peptide derived from Rabies Virus Glycoprotein that binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells. RVG enhances delivery of Mycobacterium tuberculosis antigens to antigen-presenting cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10992

Pomolic acid 3-acetate	Triterpenes Structural Classification Terpenoids Source classification Rosaceae Plants Acaena pinnatifida Ruiz & Pav.	Bacterial
Pomolic acid 3-acetate is an antitubercular agent with a MIC of 32 μM against Mycobacterium tuberculosis H₃₇Rv .

HY-N1160

Tetrahydroxysqualene	Infection Triterpenes Rhus taitensis Guill. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Anacardiaceae	Bacterial
Tetrahydroxysqualene is a triterpene, possessing antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 10.0 μg/mL. Tetrahydroxysqualene can be isolated from the methanolic extracts of Rhus taitensis Guill .

HY-N3661

(24S)-Cycloartane-3β,24,25-triol	Triterpenes Structural Classification Terpenoids Source classification Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae	Bacterial
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .

HY-120733

Calpinactam FKI-4905	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Inflammation/Immunology	Bacterial Endogenous Metabolite
Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .

HY-N11048

Amycolatopsin A	Infection Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Cancer	Bacterial
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC₅₀ values of 0.4 µM and 4.4 µM, respectively .

HY-N29777

Cabraleahydroxylactone	Triterpenes Structural Classification Terpenoids Chisocheton penduliflorus Planch. ex Hiern Source classification Plants Meliaceae	Parasite
Cabraleahydroxylactone is a dammarane triterpenoid with antimycobacterial activity against Mycobacterium tuberculosis .

HY-113289

Brassicasterol	Infection Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Akt Androgen Receptor Bacterial Drug Metabolite HSV
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-125060

Viridicatin	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Quinoline Alkaloids Disease Research Fields	Antibiotic Endogenous Metabolite
Viridicatin is a fungal metabolite from Penicillium species. Viridicatin shows slight in vitro antibiotic activity against Mycobacterium tuberculosis .

HY-111402

Pyridomycin Erizomycin; NSC 246134	Structural Classification Natural Products Microorganisms Source classification	Bacterial Antibiotic
Pyridomycin (Erizomycin) is a selective and low cytotoxic inhibitor of Mycobacterium tuberculosis that effectively targets InhA. Pyrdomycin is also an antibiotic that can be obtained from metabolites of Dactylosporangium fulvum. Pyrdomycin can be used in the study of bacterial infections such as tuberculosis .

HY-N10930

7-Oxo-ganoderic acid Z	Triterpenes Structural Classification Commiphora myrrha (Nees) Engl. Terpenoids Source classification Plants Burseraceae	Bacterial
7-Oxo-ganoderic acid Z, a terpenoid, is a nature product that could be isolated from Resina Commiphora. 7-Oxo-ganoderic acid Z has Anti-Mycobacterium tuberculosis activity .

HY-N1377

Nevadensin	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Inflammation/Immunology	Bacterial
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC₅₀ of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .

HY-N11646

Ganorbiformin B	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Bacterial
Ganorbiformin B is a lanostane triterpenoid. Ganorbiformin B shares the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T exhibits potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra .

HY-N0262

Cordycepin 5+ Cited Publications 3'-Deoxyadenosine	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Cancer	MMP Bacterial Autophagy Antibiotic
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills **Mycobacterium tuberculosis** through hijacking the bacterial adenosine kinase .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Phenols Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-135453

(-)-Pinocembrin	Structural Classification Flavonoids Flavones Polygonaceae Source classification Persicaria glabra (Willd.) M. Gomez Plants	Bacterial
(-)-Pinocembrin exhibits *anti-mycobacterium* activity against mycobacteriuum tuberculosis H37Ra with an IC₅₀ value of 1.11 mg/mL in dormant phase and 1.21 mg/mL in active phase, respectively. (-)-Pinocembrin has potent antiproliferative activity with IC₅₀ values of 1.88-11.00 mg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines .

HY-N0941

beta-Mangostin 1 Publications Verification β-Mangostin	Infection Xanthones Classification of Application Fields Source classification Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants Disease Research Fields Cancer	Bacterial Parasite Apoptosis
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .

HY-N11650

(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Bacterial
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) is an antitubercular agent with MIC value of 12.5 μg/mL for Mycobacterium tuberculosis H37Ra. (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid shows cytotoxicity with IC₅₀ value of 32 μM for Vero cells .

HY-W004570

5-Nitro-1,10-phenanthroline 5-NP	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells .

Tag:	His (5) Tag Free (3) Myc (1)
Source:	Sf9 insect cells (1) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P702605

	*CFP-10 Protein, Mycobacterium* tuberculosis (His)** esxB; cfp10; lhp; mtsA10; MT3988ESAT-6-like protein EsxB; 10 kDa culture filtrate antigen CFP-10; Secreted antigenic protein MTSA-10; Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	Others	E. coli

HY-P701867

	ClpC1 NTD Protein, Mycobacterium tuberculosis clpC1; ATP-dependent Clp protease ATP-binding subunit ClpC1	Others	E. coli
	ClpC1 NTD Protein, the ATP-dependent specificity component of the Clp protease, directs the protease to specific substrates and exhibits chaperone functions independently of ClpP. It plays a crucial role in the targeted degradation of substrates, such as the anti-sigma-E factor RseA, in the presence of ClpP2. ClpC1 NTD Protein, Mycobacterium tuberculosis is the recombinant ClpC1 NTD protein, expressed by E. coli , with tag free. The total length of ClpC1 NTD Protein, Mycobacterium tuberculosis is 145 a.a., .

HY-P701868

	*ClpC1 NTD Protein, Mycobacterium* tuberculosis (His)** clpC1; ATP-dependent Clp protease ATP-binding subunit ClpC1	Others	E. coli
	ClpC1 NTD Protein, the ATP-dependent specificity component of the Clp protease, directs the protease to specific substrates and exhibits chaperone functions independently of ClpP. It plays a crucial role in the targeted degradation of substrates, such as the anti-sigma-E factor RseA, in the presence of ClpP2. ClpC1 NTD Protein, Mycobacterium tuberculosis (His) is the recombinant ClpC1 NTD protein, expressed by E. coli , with N-6*His labeled tag. The total length of ClpC1 NTD Protein, Mycobacterium tuberculosis (His) is 145 a.a., .

HY-P701958

	PBP1A Protein, Mycobacterium tuberculosis ponA1; Penicillin-binding protein 1A; PBP-1A; Penicillin-binding protein 1*; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase	Others	E. coli
	PBP1A (penicillin-binding protein 1A) is involved in cell wall formation and plays a crucial role in the synthesis of cross-linked peptidoglycan from lipid intermediates. The enzyme has a bifunctional structure. The penicillin-insensitive transglycosylase N-terminal domain is responsible for the formation of linear glycan chains, and the penicillin-sensitive transpeptidase C-terminal domain promotes the cross-linking of peptide subunits. PBP1A Protein, Mycobacterium tuberculosis is the recombinant PBP1A protein, expressed by E. coli , with tag free. The total length of PBP1A Protein, Mycobacterium tuberculosis is 430 a.a., .

HY-P701959

	*PBP1A Protein, Mycobacterium* tuberculosis (His)** ponA1; Penicillin-binding protein 1A; PBP-1A; Penicillin-binding protein 1*; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase	Others	E. coli
	PBP1A (penicillin-binding protein 1A) is involved in cell wall formation and plays a crucial role in the synthesis of cross-linked peptidoglycan from lipid intermediates. The enzyme has a bifunctional structure. The penicillin-insensitive transglycosylase N-terminal domain is responsible for the formation of linear glycan chains, and the penicillin-sensitive transpeptidase C-terminal domain promotes the cross-linking of peptide subunits. PBP1A Protein, Mycobacterium tuberculosis (His) is the recombinant PBP1A protein, expressed by E. coli , with N-6*His labeled tag. The total length of PBP1A Protein, Mycobacterium tuberculosis (His) is 430 a.a., .

HY-P701979

	kshB Protein, Mycobacterium tuberculosis hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis is the recombinant kshB protein, expressed by E. coli , with tag free. The total length of kshB Protein, Mycobacterium tuberculosis is 358 a.a., .

HY-P701980

	*kshB Protein, Mycobacterium* tuberculosis (His)** hmp; 3-ketosteroid-9-alpha-monooxygenase; ferredoxin reductase component; 3-ketosteroid-9-alpha-hydroxylase; ferredoxin reductase component; KSH; Androsta-1; 4-diene-3; 17-dione 9-alpha-hydroxylase; Rieske-type oxygenase; RO	Others	E. coli
	The kshB protein significantly degrades cholesterol by catalyzing the introduction of the 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD), resulting in the 9OHADD intermediate. It is spontaneously converted to HSA through the cleavage of the B ring and aromatization of the A ring. kshB Protein, Mycobacterium tuberculosis (His) is the recombinant kshB protein, expressed by E. coli , with N-6*His labeled tag. The total length of kshB Protein, Mycobacterium tuberculosis (His) is 358 a.a., .

HY-P72049

	*CYP51 Protein, Mycobacterium* tuberculosis (Baculovirus, His-Myc)** cyp51; MT0788Lanosterol 14-alpha demethylase; EC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase	Others	Sf9 insect cells
	CYP51 Proteinas is a sterol 14α-demethylase that acts with an unknown physiological substrate and accepts electrons from the iron-sulfur ferredoxin Fdx. In vitro, it catalyzes the C14-demethylation of lanosterol, 24,25-dihydrolanosterol, and obtanyol, showing stereoselectivity in producing 8,14-diene. CYP51 Protein, Mycobacterium tuberculosis (Baculovirus, His-Myc) is the recombinant CYP51 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of CYP51 Protein, Mycobacterium tuberculosis (Baculovirus, His-Myc) is 451 a.a., with molecular weight of ~54.8 kDa.

Cat. No.	Product Name	Chemical Structure

HY-W013186S

Lansoprazole sulfide-d4
Lansoprazole sulfide-d₄ is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 µM intracellularly and 0.46 µM in broth[1].

HY-14881S2

Bedaquiline impurity 2-d6
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit[1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[2].

HY-14881S1

(Rac)-Bedaquiline-d6
(Rac)-Bedaquiline-d₆is the deuterium labeledBedaquiline(HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

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